. 2014 Nov 19;9(11):e113607. doi: 10.1371/journal.pone.0113607

Table 4. A significant effect of chronic lithium treatment was observed in a water maze after 4 training days.

	Treatment(p value^b)	Infection(p value^b)	Interaction(p value^b)	PM−/NaCl,(n = 12)^a	PM−/LiCl,(n = 12)^a	P value^c	PM+/NaCl,(n = 11)^a	PM+/LiCl,(n = 8)^a	P value^c
Mean proximity to virtual platform [cm]	0.0059 ^**	0.2183	0.4583	60.8±10.8	53.3±12.6	0.1948	67.8±9.7	55.0±12.6	0.0422 ^*
Platform crossings [n]	0.0054 ^**	0.4066	0.8350	1 (0, 5)^d	2 (1, 5)^d	0.0805	1 (0, 3)^d	2.5 (0, 5)^d	0.0895
Time in platform quadrant [s]	0.0262 ^*	0.3610	0.8717	8.6±3.6	11.3±3.9	0.1221	7.8±2.6	10.1±3.9	0.3071

In a probe trial on day 5 animals treated with lithium swum closer to the previous location of the platform.

values are mean ± SD;

2way ANOVA;

Sidak’s multiple comparisons test;

median (minimum, maximum); PM, pneumococcal meningitis;

*p<0.05;

**p<0.01.