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. 2014 Oct 13;6(11):1359–1370. doi: 10.15252/emmm.201302627

Figure 2. Drug modification of epigenetic regulation.

Figure 2

(A) Bromodomain readers recognize modified residues on histone tails which can lead to unraveling of the DNA/histone complex contingent on the bromodomain-containing complex composition. Unwound DNA is available for transcription complex interaction and transcription. (B) Unwound, transcriptionally active DNA reliant on bromodomain-containing complexes can be therapeutically targeted. Drugs blocking the bromodomain/histone tail modification interaction can prevent the helicase activity by bromodomain-containing complexes, thus stereohindering transcription regulators and silencing genes.