Table 3.
p16/Ki-67 positivity in histology categories stratified by age and HPV16 status
| Normal | Atypical Metaplasia | CIN1 | CIN2 | CIN3 | Cancer | Total | |
|---|---|---|---|---|---|---|---|
| Total | 112 | 25 | 228 | 169 | 83 | 6 | 623 |
| % DS+ | 26.8 | 48.0 | 46.5 | 82.8 | 92.8 | 100.0 | 59.6 |
| HPV16− / <30 | 52 | 14 | 131 | 85 | 18 | 0 | 300 |
| % DS+ | 25.0 | 64.3 | 46.6 | 81.2 | 77.8 | N/A | 55.3 |
| HPV16− / 30+ | 41 | 3 | 64 | 22 | 11 | 3 | 144 |
| % DS+ | 24.4 | 0 | 31.3 | 68.2 | 90.9 | 100 | 40.3 |
| HPV16+ / <30 | 14 | 5 | 25 | 52 | 34 | 0 | 130 |
| % DS+ | 28.6 | 40.0 | 72.0 | 92.3 | 97.1 | N/A | 80.8 |
| HPV16+ / 30+ | 4 | 1 | 6 | 8 | 19 | 3 | 47 |
| % DS+ | 50.0 | 100.0 | 83.3 | 75.0 | 100.0 | 100.0 | 87.8 |
DS+=p16/Ki-67 double-stain positive