Table 4.

Clinical performance of p16/Ki-67 in a colposcopy population

	Sensitivity	Specifiticy	PPV	NPV	Referral
All Women CIN2+	86.4% (81.5 – 90.2)	59.5% (54.2 – 64.5)	60.1% (54.9 – 65.1)	86.1% (81.1 – 90.0)	59.55% (55.7 – 63.3)
All Women CIN3+	93.2% (85.3 – 97.2)	46.1% (41.8 – 50.4)	22.3% (18.3 – 27.0)	97.6% (94.6 – 99.0)
<30 yo and CIN2+	86.8% (81.0 – 91.1)	55.4% (48.9 – 61.7)	60.4% (54.3 – 66.2)	84.3% (77.5 – 89.4)	63.19% (58.4 – 67.6)
<30 yo and CIN3+	90.4% (78.2 – 96.4)	40.5% (35.6 – 45.7)	17.2% (13.0 – 22.3)	96.9% (92.4 – 98.8)
≥30 yo and CIN2+	84.8% (73.4 – 92.1)	67.5% (58.3 – 75.6)	58.9% (48.3 – 68.8)	89.0% (80.3 – 94.3)	51.08% (44.0 – 58.2)
≥30 yo and CIN3+	97.2% (83.8 – 99.9)	60.0% (51.7 – 67.8)	36.8% (27.4 – 47.4)	98.9% (93.2 – 99.9)