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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Anesthesiology. 2014 Dec;121(6):1270–1280. doi: 10.1097/ALN.0000000000000337

Fig. 2. TLR4 deficiency leads to improved survival in endotoxin shock but decreased survival in low grade polymicrobial sepsis.

Fig. 2

Mice were subjected to CLP or lipopolysaccharide administration and observed for mortality. A. Survival curve in CLP model. n = 22 in WT group, n=21 in TLR4-def group. *** P=0.0001; B. Survival curve in endotoxin shock model. n=5 in each group. ** P=0.003. CLP, cecum ligation and puncture; TLR, Toll-like receptor; WT, wild type. Log-rank test was used to analyze statistic difference in survival between the two groups.