Mice were subjected to sham or CLP surgery. Serum was collected 24 h after surgery. Each error bar represents the mean ± SE. Two-way ANOVA was used for statistical analysis and Bonferroni post hoc tests was applied for difference between groups. * P<=0.05, ** P<0.01, *** P<0.001, n=3 in sham group, n=7 in CLP group. N.D., not detectable; BUN, blood urea nitrogen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CLP, cecum ligation and puncture; WT, wild type; TLR, Toll-like receptor.