Table 4.
Break-Even Analysis of Unit Cost of MMR4 Test Kit Relative to Selected HNPCC Screening Strategies
| Screening Strategy | Cost Per CRC Case Screened ($) | True Detection Rate (%) | NNT | Break-Event Cost of Unit MMR4 Test ($) |
|---|---|---|---|---|
| #1 | $1,402 | 0.02716 | 37 | 1,518 |
| #2 | $611 | 0.02649 | 38 | 678 |
| #3 | $517 | 0.02403 | 42 | 633 |
| #4 | $644 | 0.02417 | 41 | 784 |
| 20% RBG inapplicable | ||||
| #1 | 1,462 | 0.021728 | 46 | 2,009 |
| #2 | 671 | 0.021192 | 47 | 945 |
| #3 | 577 | 0.019224 | 52 | 896 |
| #4 | 704 | 0.019336 | 52 | 1,087 |
| Genetic-based Strategy | ||||
| #6 | 1,896 | 0.02642 | 38 | 2,119 |
| #7 | 2,024 | 0.02657 | 38 | 2,262 |
| #8 | 2,315 | 0.02913 | 34 | 2,315 |
| #9 | 2,319 | 0.02912 | 34 | 2,319 |
| #10 | 2,577 | 0.02928 | 34 | 2,577 |
NNT= number need-to-test to detect one LS case.