| Test | Cost ($) | Reference |
|---|---|---|
|
| ||
| RBG cost of genetic consultation | 150* | 1 |
|
| ||
| MLH1, MSH2, MSH6 and PMS2 full gene sequencing | 4000* | 2 |
|
| ||
| MLH1, MSH2, and MSH6 deletion/duplication analysis | 2200* | 2 |
|
| ||
| MLH1 full gene sequencing | 1150 | 2 |
| 1018 | 3 | |
| 1200 | 4 | |
| 900* | 5 | |
| 1342 | 6 | |
| 1290 | 7 | |
|
| ||
| MLH1 deletion/duplication | 1500 | 2 |
| 300* | 3 | |
| 470 | 4 | |
| 505 | 5 | |
| 474 | 6 | |
|
| ||
| MLH1 hypermethylation analysis | 439 | 3 |
|
| ||
| MSH2 full gene sequencing | 1150 | 2 |
| 996 | 3 | |
|
4 | |
| 1342 | 5 | |
| 1090 |
6 7 |
|
|
| ||
| MSH2 deletion/duplication | 1500 | 2 |
| 300* | 3 | |
| 470 | 4 | |
| 505 | 5 | |
| 474 | 6 | |
|
| ||
| MSH6 full gene sequencing | 1150 | 2 |
| 1018 | 3 | |
| 1200 | 4 | |
| 900* | 5 | |
| 1102 | 6 | |
| 1050 | 7 | |
|
| ||
| MSH6 deletion/duplication | 1500 | 2 |
| 300* | 3 | |
| 470 | 4 | |
| 505 | 5 | |
| 474 | 6 | |
|
| ||
| PMS2 full gene sequencing | 1400 | 2 |
| 1870 | 4 | |
| 1342 | 6 | |
| 980* | 7 | |
|
| ||
| PMS2 deletion/duplication | 470* | 4 |
| 474 | 6 | |
|
| ||
| IHC(MLK1, MSH2, MSH6, and PMS2) | 500* | 2 |
| 558 | 3 | |
|
| ||
| MSI | 415* | 2 |
| 493 | 3 | |
|
| ||
| BRAF mutation analysis | 314* | 3 |
Abbreviations: RBG, Revised Bethesda Guidelines; IHC, immunohistochemistry; MSI, microsatellite instability.
References for cost
1
Resnick K, Straughn JM, Backes F, Hampel H, Matthews KS, Cohn DE. Lynch syndrome Screening Strategies among Newly Diagnosed Endometrial Cancer Patients. Obstetrics & Gynecology 2009;114:3:530–536
2
Emory Genetics Labs
3
Mayo Medical Laboratories
4
BCM labs
5
Harvard Partners
6
University Hospitals Case Medical Center
7
Prevention Genetics