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An 11 yo patient with radiographic changes in the hands and wrist during treatment with pazopanib. Hand/wrist radiographs are not routinely used to monitor growth plate toxicity, however these images obtained at baseline (A) and after 6 cycles of therapy with pazopanib (B) clearly demonstrate that widening of the distal radial physis (arrows) may also occur in response to anti-angiogenic therapy.
