Table II.
Characteristics of 34 patients with neuroblastoma who developed a second malignant neoplasm compared with 2767 patients with neuroblastoma who did not develop second malignancies.
| Characteristic | Neuroblastoma with second malignancies n = 34 (1.2%) |
Neuroblastoma n = 2767 (98.8%) |
p-valuea |
|---|---|---|---|
|
| |||
| Median age | 1.5 years | 1 year | 0.39 |
| Range | 0–21 years | 0–29 years | |
|
| |||
| Male | 18 (52.9%) | 1459 (52.7%) | 1.00 |
|
| |||
| Race | |||
| White | 27 (79.4%) | 2240 (81.0%) | 0.59 |
| Black | 3 (8.8%) | 318 (11.4%) | |
| Asian | 4 (11.8%) | 182 (6.6%) | |
| Not available | 0 (0%) | 27 (1.0%) | |
|
| |||
| Ethnicity | |||
| Hispanic | 3 (8.8%) | 398 (14.4%) | 0.47 |
| Non-Hispanic | 31 (91.2%) | 2369 (85.6%) | |
|
| |||
| Stage | |||
| Distant Metastasis | 20 (58.8%) | 1207 (43.6%) | 0.09 |
| No Distant Metastasis | 9 (26.5%) | 1312 (47.4%) | |
| Unknown | 5 (14.7%) | 248 (9.0%) | |
|
| |||
| Histology | |||
| Ganglioneuroblastoma | 3 (8.8%) | 401 (14.5%) | 0.47 |
| Neuroblastoma | 31 (91.2%) | 2366 (85.5%) | |
|
| |||
| Era of Diagnosis | |||
| 1973–1989 | 20 (58.8%)b | 803 (29.0%) | N/A |
| 1990–1996 | 4 (11.8%) | 624 (22.6%) | |
| 1997–2006 | 10 (29.4%) | 1340 (48.4%) | |
|
| |||
| Risk Group | |||
| High | 13 (38.2%) | 933 (33.7%) | 0.18 |
| Low | 17 (50.0%) | 1677 (60.6%) | |
| Not definable | 4 (11.8%) | 157 (5.7%) | |
a
We used t-test for age, chi-square tests for gender, and fisher’s exact tests for race, ethnicity, metastasis stage, histology.
b
Radiation was used for the primary neuroblastoma in 11 patients from Era 1, 1 from Era 2 and 4 from Era 3.