. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: Cancer Causes Control. 2014 Sep 16;25(12):1717–1723. doi: 10.1007/s10552-014-0462-7

Table 3.

ORs and 95% CIs for associations between plasma MMP1, 3, and 7 quintile and breast cancer tumor size and lymph node involvement among women in the Nurses’ Health Study, 1992 – 2000

	Quintile					P-value, test for trend	P- heterogeneity
	1	2	3	4	5	P-value, test for trend	P- heterogeneity
MMP1, ng/mL	≤0.88	0.89 –1.46	1.47 –2.12	2.13 –3.34	>3.34
Tumor size
≤2.0 cm (572 cases, 796 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.0 (0.7, 1.4)	0.8 (0.6, 1.2)	0.9 (0.6, 1.2)	0.9 (0.6, 1.3)	0.39
							0.89
>2.0 cm (186 cases, 796 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.1 (0.7, 1.8)	1.0 (0.6, 1.6)	0.9 (0.5, 1.5)	0.9 (0.5, 1.5)	0.47
Lymph node involvement
No lymph nodes (524 cases, 796 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.1 (0.8, 1.6)	0.8 (0.6, 1.2)	0.9 (0.6, 1.3)	0.8 (0.6, 1.2)	0.19
							0.37
Any lymph nodes (183 cases, 796 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	0.9 (0.5, 1.5)	0.9 (0.5, 1.5)	0.8 (0.5, 1.4)	1.1 (0.6, 1.8)	0.97
MMP3, ng/mL	≤7.95	7.96 – 9.70	9.71 – 11.57	11.58 – 14.03	>14.03
Tumor size
≤2.0 cm (567 cases, 792 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	0.9 (0.7, 1.3)	1.0 (0.7, 1.4)	0.9 (0.6, 1.3)	1.0 (0.7, 1.4)	0.97
							0.74
>2.0 cm (186 cases, 792 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.1 (0.7, 1.9)	1.7 (1.0, 2.7)	1.0 (0.6, 1.7)	1.2 (0.7, 2.0)	0.71
Lymph node involvement
No lymph nodes (518 cases, 792 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	0.9 (0.6, 1.3)	1.0 (0.7, 1.4)	0.8 (0.6, 1.2)	0.9 (0.6, 1.3)	0.52
							0.11
Any lymph nodes (185 cases, 792 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.1 (0.7, 2.0)	1.7 (1.0, 2.8)	1.1 (0.6, 2.0)	1.4 (0.8, 2.5)	0.23
MMP7, ng/mL	≤0.64	0.65 – 0.82	0.83 – 1.01	1.02 – 1.29	>1.29
Tumor size
≤2.0 cm (575 cases, 800 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.2 (0.9, 1.8)	1.3 (0.9, 1.9)	1.4 (1.0, 2.0)	1.3 (0.9, 1.9)	0.10
							0.32
>2.0 cm (186 cases, 800 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.0 (0.6, 1.6)	1.2 (0.7, 2.0)	1.2 (0.7, 2.0)	0.9 (0.5, 1.6)	0.93
Lymph node involvement
No lymph nodes (527 cases, 800 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.2 (0.8, 1.7)	1.2 (0.8, 1.7)	1.3 (0.9, 1.9)	1.1 (0.8, 1.6)	0.52
							0.24
Any lymph nodes (184 cases, 800 controls)
Multivariate OR (95% CI)^a	1.0 (ref.)	1.3 (0.7, 2.2)	1.7 (1.0, 2.9)	1.6 (0.9, 2.7)	1.5 (0.9, 2.7)	0.10

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; MMP, matrix metalloproteinase

Multivariate polytomous logistic regression adjusting for matching factors and body mass index at blood draw (continuous), age at menarche (<12 years, 12 years, 13 years, ≥14 years), alcohol consumption in 1990 (continuous), postmenopausal hormone use (premenopausal, postmenopausal never use, past use, current use <5 years, current use ≥5 years), age at first birth/parity (nulliparous, 1–4 children with age at first birth <25 years, 1–4 children with age at first birth 25–29 years, 1–4 children with age at first birth ≥30 years, ≥5 children with age at first birth <25 years, ≥5 children with age at first birth ≥25 years), family history of breast cancer (yes/no), and history of benign breast disease (yes/no)