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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Neurochem. 2014 Sep 4;131(5):566–572. doi: 10.1111/jnc.12929

Figure 1. 5-HT2C receptor-mediated inhibition by RO 60-0175 of the stress-induced increase in 5-HT turnover in BALB/c and C57BL/6J mice.

Figure 1

A) Effect of restraint stress on the 5-HT turnover [5-HIAA/5-HT ratio; means ± S.E.M.] in the hippocampus of C57BL/6J (n= 14–17) and BALB/c (n= 20–29) WT mice. B) The effects of RO 60-0175 (RO; 3 mg/kg i.p.) are presented as a percentage (means ± S.E.M.) of the 5-HIAA/5-HT ratio of saline-treated mice of the C57BL/6J (n=14–16) and BALB/c (n=22–31) strain. ***p<0.001, two-tail Student’s t-test.