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. Author manuscript; available in PMC: 2015 Nov 1.

Published in final edited form as: Circ Cardiovasc Imaging. 2014 Sep 16;7(6):863–871. doi: 10.1161/CIRCIMAGING.114.002411

A) The 4 cardiac structural and functional parameters shown to have significant independent association with the presence of sarcomere gene mutations in subclinical hypertrophic cardiomyopathy. B) Receiver operating characteristics (ROC) curve containing the 4 parameters and using as a reference, patient classification according to study criteria for inclusion of carriers and controls, showed an area under the curve (AUC) of 0.85. Diagonal reference line is also provided. C) In this case-control population we used a 2x2 contingency table to calculate the percentage of rulings that agreed with genetic diagnosis and obtained a sensitivity of 75% (95 % confidence intervals [CI] 64 – 84) and specificity, 84%, (95 % CI 73 - 91).

Other abbreviations as in Figure 1.

A) The 4 cardiac structural and functional parameters shown to have significant independent association with the presence of sarcomere gene mutations in subclinical hypertrophic cardiomyopathy. B) Receiver operating characteristics (ROC) curve containing the 4 parameters and using as a reference, patient classification according to study criteria for inclusion of carriers and controls, showed an area under the curve (AUC) of 0.85. Diagonal reference line is also provided. C) In this case-control population we used a 2x2 contingency table to calculate the percentage of rulings that agreed with genetic diagnosis and obtained a sensitivity of 75% (95 % confidence intervals [CI] 64 – 84) and specificity, 84%, (95 % CI 73 - 91).

Other abbreviations as in Figure 1.