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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Leukemia. 2014 May 14;29(1):218–229. doi: 10.1038/leu.2014.159

Figure 2. HLA-A2 restricted IFN-γ production by SMM MP-CTL against MM cells.

Figure 2

Figure 2

One week after the fourth stimulation, SMM MP-CTL were analyzed for IFN-γ production upon stimulation with various MM cell lines. Representative flow cytometric analysis demonstrates increased IFN-γ production by SMM MP-CTL in response to HLA-A2+ MM cells (McCAR), but not HLA-A2- MM cells (MM1S, RPMI) or NK-sensitive K562 cells (Figure 2A). MP-CTL generated from additional HLA-A2+ SMM patients (n=4) confirmed HLA-A2-restricted IFN-γ production to MM cells, but not to NK sensitive K562 cells (Figure 2B).