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. 2014 Nov 14;11:25. doi: 10.1186/2045-8118-11-25

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© Chen et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Membrane transporters (potentially) involved in the CNS distribution of cefadroxil. Several references were used to inform this schematic representation [16, 39–41]. There is much debate regarding the isoforms and membrane localization of MRPs at the BBB. There is, though, considerable evidence for some MRPs having an apical distribution clearing substrates to blood as depicted. There is also functional evidence for the probenecid-inhibitable efflux of cefadroxil from brain cells , the nature of which is uncertain but may include OAT, MRP and/or OATP transporters. BL represents the basolateral membrane, AP the apical membrane, and EP the ependyma.

Inline graphic — Membrane transporters (potentially) involved in the CNS distribution of cefadroxil. Several references were used to inform this schematic representation [16, 39–41]. There is much debate regarding the isoforms and membrane localization of MRPs at the BBB. There is, though, considerable evidence for some MRPs having an apical distribution clearing substrates to blood as depicted. There is also functional evidence for the probenecid-inhibitable efflux of cefadroxil from brain cells , the nature of which is uncertain but may include OAT, MRP and/or OATP transporters. BL represents the basolateral membrane, AP the apical membrane, and EP the ependyma.