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. 2014 Nov 11;6(1):25. doi: 10.1186/1868-7083-6-25

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© Wang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Treatment with 5-azaC decreased CD11a regulatory sequence methylation and increased CD11a expression in normal CD4 ⁺ T cells. (A and B) CD11a promoter methylation patterns in (A) untreated CD4⁺ T cells and (B) 5-azaC-treated CD4⁺ T cells from five healthy subjects. (C and D) Treatment of CD4⁺ T cells with 5-azaC caused significant (C) demethylation of the same promoter region accompanied by (D) demethylation of Alu element relative to untreated CD4⁺ T cells. (E and F) Both (E) mRNA and (F) protein expression of CD11a were more pronounced in 5-azaC-treated CD4⁺ T cells than in untreated CD4⁺ T cells. (G) The mean DNA methylation levels of the CD11a promoter were inversely correlated with the relative mRNA level in 5-azaC treated CD4⁺ T cells.