Table 1.
Hematological analysis of line Slc12a1 I299F
| |
Males |
Females |
||
|---|---|---|---|---|
| Parameter | Homozygous mutants | Heterozygous mutants | Homozygous mutants | Heterozygous mutants |
| WBC (103/μl) |
8.4 ± 0.9a |
6.4 ± 0.3 |
7.0 ± 0.2 |
6.8 ± 0.5 |
| RBC (106/μl) |
8.8 ± 0.1a |
9.1 ± 0.1 |
9.0 ± 0.2 |
9.0 ± 0.1 |
| PLT (103/μl) |
680 ± 14c |
760 ± 12 |
671 ± 21 |
704 ± 22 |
| HGB (g/dl) |
14.2 ± 0.2b |
14.9 ± 0.1 |
14.8 ± 0.3 |
14.5 ± 0.2 |
| HCT (%) |
43.5 ± 0.5b |
46.1 ± 0.4 |
45.3 ± 0.8 |
45.0 ± 0.4 |
| MCV (fl) |
49.5 ± 0.2b |
50.4 ± 0.2 |
50.4 ± 0.3 |
50.1 ± 0.2 |
| MCH (pg) |
16.1 ± 0.1 |
16.3 ± 0.1 |
16.4 ± 0.1 |
16.1 ± 0.1 |
| MCHC (g/dl) | 32.6 ± 0.2 | 32.3 ± 0.1 | 32.7 ± 0.2 | 32.3 ± 0.1 |
WBC, white blood cell count; RBC, red blood cell count; PLT, platelet count; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration.
22-week-old mice were tested. No. per genotype and sex: n = 8–10. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01, cP < 0.001.