Table 2.

Magnetic resonance imaging (MRI) parameter values in frontal white matter, posterior periventricular white matter, centrum semiovale and thalamus in patients and controls (mean ± SD)

Region	MD (×10−3  mm2/s)			FA
	W1	W4	W12	W1	W4	W12
Patients
LFWM	0.824 ± 0.095a	0.815 ± 0.080	0.904 ± 0.107bc	0.388 ± 0.056a	0.374 ± 0.062	0.313 ± 0.054bc
RFWM	0.825 ± 0.089	0.821 ± 0.088	0.831 ± 0.084	0.387 ± 0.062	0.385 ± 0.063	0.395 ± 0.063
LPPWM	0.837 ± 0.102	0.836 ± 0.096	0.839 ± 0.087	0.452 ± 0.062	0.447 ± 0.061	0.431 ± 0.063
RPPWM	0.853 ± 0.114	0.835 ± 0.094	0.822 ± 0.085	0.444 ± 0.053	0.451 ± 0.059	0.447 ± 0.053
LCS	0.766 ± 0.112	0.754 ± 0.087	0.729 ± 0.104	0.387 ± 0.058	0.381 ± 0.060	0.362 ± 0.055
RCS	0.772 ± 0.110	0.765 ± 0.098	0.783 ± 0.105	0.383 ± 0.059	0.391 ± 0.062	0.393 ± 0.064
L thalamus	0.846 ± 0.080a	0.830 ± 0.097	0.949 ± 0.065bc	0.338 ± 0.038	0.334 ± 0.037	0.323 ± 0.032
R thalamus	0.839 ± 0.788	0.840 ± 0.081	0.841 ± 0.083	0.344 ± 0.042	0.344 ± 0.043	0.342 ± 0.040
Controls
LFWM	0.804 ± 0.109			0.421 ± 0.057
LPPWM	0.824 ± 0.099			0.451 ± 0.057
LCS	0.764 ± 0.093			0.392 ± 0.063
L thalamus	0.836 ± 0.069			0.345 ± 0.051

Abbreviations: FA, fractional anisotropy; LCS, left centrum semiovale; LFWM, left frontal white matter; LPPWM, left posterior periventricular white matter; LCS, left centrum semiovale; L thalamus, left thalamus; MD, mean diffusivity; R thalamus, right thalamus; RCS, right centrum semiovale; RFWM, right frontal white matter; RPPWM, right posterior periventricular white matter; W1, the first week; W4, the fourth week; W12, the 12th week.

^aP < 0.05, LSD test, comparison between W1 and W12; ^bP < 0.05, Student’s t-test, comparison between the control and patient groups; ^cP < 0.05, Student’s t-test, comparison in the left and right region of patients at W12.

The controls were examined only once when they were recruited.