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. 2014 Aug 19;21(1):76. doi: 10.1186/s12929-014-0076-0

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Copyright © 2014 Chen et al.; licensee BioMed Central

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Difference in methylation patterns. (a) Sequence of human IL-12 p35 promoter. The sequences of the PCR used to perform pyrosequencing are indicated by underline. (b) Whole blood methylation % of IL-12p35 promoter region. Each graphic represents each CpG island (pos-1, 2, 3 and 4). The percentages of methylation are represented by bars. The black bars represent adult and the white bars represent newborn percentage of methylation of the IL-12p35 promoter site.