Table 2.
Circulating oxidative stress biomarkers and asymmetrical dimethylarginine (ADMA) and dimethylarginine dimethylaminohydrolase (DDAH)
|
Baseline |
PR 2 h |
PR 4 h |
PR 72 h |
|
|---|---|---|---|---|
| (n = 8) | (n = 9) | (n = 6) | (n = 8) | |
|
Plasma hs-cTnT, ng/L |
61 [20-91] |
3732 [3277-6218]** |
3469 [2428-4930]* |
44 [39-1610] |
|
Plasma IsoP, pg/mL |
235.6 ± 28.8 |
206.2 ± 14.9 |
306.6 ± 21.6* |
216.6 ± 30.0 |
|
Plasma 8-OHG, pg/mL |
742.9 ± 79.3 |
1044.5 ± 71.1* |
914.9 ± 104.1 |
846.9 ± 14.7 |
|
Plasma GSH, μmol/mL |
0.146 ± 0.030 |
0.099 ± 0.004 |
0.095 ± 0.013 |
0.136 ± 0.023 |
|
Plasma ADMA, μmol/L |
0.767 ± 0.10 |
0.641 ± 0.07 |
0.468 ± 0.06* |
0.601 ± 0.07 |
|
Myocardial ADMA, nmol/mg prot |
0.083 ± 0.01 |
0.052 ± 0.01 |
0.043 ± 0.01 |
0.080 ± 0.02 |
| Myocardial DDAH, nmol/mg prot | 77.5 ± 12.7 | 73.5 ± 7.2 | 79.0 ± 10.4 | 90.0 ± 12.8 |
PR, post resuscitation; 8-OHG, 8-hydroxyguanosine; hs-cTnT, high-sensitivity cardiac troponin T; IsoP, isoprostanes; GSH, glutathione S-transferase.
Parametric data are shown as mean ± SEM; Non-parametric data are shown as median [25-75 percentile].
*p < 0.05 vs. Baseline; **p < 0.01 vs. Baseline.