Table 4.

Chemical inhibitors that target Snail1-induced EMT

Name	Inhibits	Effect	Known limitations	Reference
GN25, GN29	Snail/p53 interaction	Reduced proliferation, tumor progression; increased tumor regression	Only effective in K-Ras activated cancer cells and on wild-type p53	[174],[175]
Co(III)-Ebox	Snail/E-cadherin interaction	Increased E-cadherin expression		[176]
Tranylcypromine	LSD1/LSD2	Decreased Snail’s effects on EMT markers		[177]
Trichostatin A	HDAC1/HDAC2	Reversed EMT marker expression		[177]
Pargyline	LSD1	Abrogated Snail-induced EMT		[177]
LBH589	HDAC	Abrogated Snail-induced EMT		[177]
Entinostat	HDAC	Increased E-cadherin and cytokeratin 18 expression, Decreased Twist, Snail, vimentin, N-cadherin; encouraged epithelial morphology; decreased cell migration		[178]