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. Author manuscript; available in PMC: 2014 Nov 20.
Published in final edited form as: Pain. 2013 Dec 16;155(3):617–628. doi: 10.1016/j.pain.2013.12.018

Figure 3. Systemic dexmedetomidine dose-dependently enhances spontaneous IPSCs in the SG.

Figure 3

A) Systemic dexmedetomidine (left trace, 0.1 μg/kg) and clonidine (right trace, 40 μg/kg) elicited barrages of spontaneous IPSCs (holding potential of 0 mV with a cesium-based based solution). The traces below are shown on an expanded time base to demonstrate the individual IPSCs.

B) Dexmedetomidine dose-dependently elicits barrages of spontaneous IPSCs.

C) Summary plot showing the enhancement of IPSCs (open circles) at dexmedetomidine doses (<10 μg/kg) that are lower than those required to induce outward currents (closed circles).

D) The cumulative probability plots for the inter-event interval and amplitude of spontaneous IPSCs (from the left trace in A). Dexmedetomidine at a dose of 0.1 μg/kg significantly increased the frequency (p < 0.01) and amplitude (p < 0.01) of spontaneous IPSCs (Kolmogorov-Smirnov test).