Table 3.
Radiosensitization effects of YM155 on Eca109 xenograft mouse model
| Treatment | Doubling time (days) | Absolute growth delay (days) a | Normalized growth delay (days) b | Enhancement factor |
|---|---|---|---|---|
|
Control |
5.7 ± 0.5 |
0 |
|
|
|
IR |
8.0 ± 2.0 |
2.3 (8.0-5.7) |
|
|
|
YM155 |
9.0 ± 1.6 |
3.3 (9.0-5.7) |
|
|
| IR + YM155 | 17.6 ± 6.5 | 11.9 (17.6-5.7) | 8.6 (11.9-3.3) | 3.75 (8.6/2.3) |
aAbsolute growth delay, the doubling tumor time of treatment group minus that of control group; bNormalized growth delay, the time of absolute growth delay of tumor in IR combined with YM155 group minus that of YM155 group.