Table 2.

Annotation of aberrant genes relevant to sunitinib sensitivity

CNV
HGNC	Alteration	CN
RET	H.AMP	4.4
KRAS	H.AMP	4.2
EGFR	H.AMP	4.7
PTEN	H.DEL	0.9
SNV
HGNC	Alteration	Consequence	Quality
AKT1	c. G529A p. A117T	Likely benign	Low

Next generation sequencing of unusual responder patient with testicular cancer indicated tumor harboring multiple copy number aberrations. Only 5 alterations were found to have reported relevant information in tumors/cells treated with sunitinib: RET amplification, PTEN loss, EGFR and KRAS amplification.

HGNC – Hugo genome nomenclature committee, CNV, copy number variation, SNV- Single nucleotide variants.

NOTE: Genomic alterations detected may or may not have reported altered protein function.