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. 2014 Aug 3;12:74. doi: 10.1186/1477-7827-12-74

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Copyright © 2014 Wu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The percentage of Th17 and Treg cells in peripheral blood mononuclear cells and the Th17/Treg ratio varies in patients with a successful pregnancy after immunotherapy. The percentage of Th17 and Treg cells in peripheral blood mononuclear cells were detected by flow cytometry in patients with successful pregnancy after immunotherapy. To date, 13 of the 20 patients have become newly pregnant. Of the 13, the 11 patients did not miscarry (successful group). (a) The percentage of Th17 cells in peripheral blood mononuclear cells significantly decreased after immunotherapy. The percentage of Treg cells in peripheral blood mononuclear cells significantly increased after immunotherapy (P < 0.01, paired t-test). Bar represents the CD4+/IL-17A + cell frequency and the means ± S.E. are indicated (b) The Th17/Treg ratio in peripheral blood mononuclear cells significantly decreased after immunotherapy (P < 0.01, paired t-test). Bar represent the frequency of CD4+/CD25bright/Foxp3+ cells and the means ± S.E. are indicated. Representative CD4+/IL-17A + flow cytometry plots from patients with successful pregnancies were shown before (c) and after (d) immunotherapy. Representative CD4+/CD25bright Foxp3+ flow cytometry plots from patients with successful pregnancies were shown before (e) and after (f) immunotherapy.