A.
Top: Significant genomic aberrations in the prostate oncogenome from the MSKCC CGH dataset adopted from (Taylor et al., 2010). Bottom: Copy number landscape of seven patient derived organoid lines and six publically available prostate cancer cell lines using array CGH data. Shades of red and blue represent level of gain and loss. B. Copy number changes at chromosome 3p14 containing FOXP1, SHQ1, and RYBP, the CHD1 locus, the PTEN locus, the TMPRSS2-ERG locus and the AR locus. Arrows point to highly focal regions of biallelic deletion. See also Figure S1 for zoomed view together with corroborating RNA-Seq and WES reads.