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. 2014 Aug 4;13:182. doi: 10.1186/1476-4598-13-182

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Copyright © 2014 Rosemann et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Binding sites for transcription factors and regulatory proteins in the murine and the human Rb1 promoter (below the line) and position of the reported indel polymorphisms (above line). TF binding sites in murine sequence as predicted by MatInspector software [33,34] and as annotated by Zacksenhaus [32] (Genebank Acc.-No. M86180). TF binding sites in human sequence as predicted by [36]. Promoter core consisting of steroid hormone response elements (HRE) and Sp1, ATF and E2F binding sites are highly conserved. Retinoblastoma control elements (RCE) in the human promoter are according to [36] and predicted in the murine promoter using published RCE core sequences [48].