Table 3.

Anti-proliferative and pro-apoptotic functions of PXR

Anti-proliferative functions of PXR
Tissue specification	PXR activation approach	References
Colon cancer	Ectopic expression of PXR significantly inhibited anchorage-independent growth and cell proliferation in vitro and xenograft tumor growth in vivo via G0/G1 cell-cycle arrest.	[50]
Liver and colon carcinogenic tissue	PXR overexpression sensitized cells to paraquat-induced oxidative stress when treated with PXR agonists.	[51]
Pro-apoptotic functions of PXR
Tissue specification	PXR activation approach	Reference
Breast cancer	SXR activators inhibited cell proliferation and induced apoptosis in breast cancer cells. Wild-type p53 was mechanistically required for the anti-proliferative phenotype of PXR.	[37]