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. 2014 Nov 13;63(12):4326–4337. doi: 10.2337/db14-0326

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© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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Aortic PWV, a measure of arterial stiffness, is reduced in SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR^−/− mice. Male Msx1(fl/fl);Msx2(fl/fl);LDLR^−/− mice and SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR^−/− male sibling cohorts were challenged with HFD for 3 months then evaluated by Doppler echocardiography to quantify aortic stiffness as previously described using PWV. A: Compared with Msx1(fl/fl);Msx2(fl/fl);LDLR^−/− controls, SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR^−/− mice exhibited significantly reduced aortic arch PWV (n = 4 per genotype). B: Aortic diameters did not differ between genotypes as assessed by echocardiography. Recall that although calcification was decreased, no change in aortic wall thickness or collagen content was observed (Fig. 2). See results for discussion. NS, not significant.