Figure 1.

Type 1 diabetes association results on 16p13.13. A total of 939 SNPs (genotyped and imputed) were tested for association with type 1 diabetes in 3,070 multiplex families (12,485 individuals) using the TDT. The log₁₀ of the P value for this test is plotted relative to the physical position on the chromosome for each SNP. The most significant results were obtained for rs34306440 (P = 5.74 × 10⁻⁶), marked in purple. The color of all other SNPs indicates pairwise linkage disequilibrium with rs34306440, as measured by the r² statistic. Symbol shapes indicate those SNPs genotyped only on the custom panels (snowflake), genotyped only on the ImmunoChip (circle), and genotyped on both panels (square). cM/Mb, centimorgan/megabase.