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. 2014 Nov 13;63(12):4172–4185. doi: 10.2337/db14-0026

Figure 3.

Figure 3

Deletion of MPO reduces inflammatory response in WAT. WT and MPO−/− mice were fed the HFD for 6 weeks. A: Representative images of WAT immunostained for the macrophage marker CD68. B: Quantification of immunohistochemical staining of CD68 in WAT sections (n = 4). *P < 0.05 vs. WT. C: Expression of F4/80 mRNA was measured by quantitative real-time PCR (n = 4). *P < 0.05 HFD vs. ND; †P < 0.05 MPO−/− vs. WT. D: Cytokine mRNAs in WAT were measured by quantitative real-time PCR (n = 4). *P < 0.05 MPO−/− vs. WT. E: WT and MPO−/− mice were fed the HFD for 16 weeks. Expression of iNOS in WAT was analyzed by using immunohistochemistry.