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. 2014 Nov 13;63(12):4057–4063. doi: 10.2337/db14-0595

Figure 1.

Figure 1

Generation and characterization of FGF21 LivKO mice. A–F: 12- to 14-week-old male WT (FGF21fl/fl) and FGF21 LivKO mice were either ad libitum–fed chow, fasted 24 h, or fasted 24 h and then refed for 15 min via oral gavage (n = 5–8/group). Levels of hepatic Fgf21 mRNA (A), eWAT Fgf21 mRNA (B), plasma FGF21 protein (C), plasma glucose (D), plasma insulin (E), and plasma adiponectin (F) in the indicated mice are shown. G: Levels of plasma glucose and area under the curve (AUC) from WT and FGF21 LivKO mice during a GTT (n = 5–6/group). Data are presented as mean ± SEM. Different lowercase letters represent statistical significance between genotypes (a, P < 0.05; b, P < 0.01; d, P < 0.001). *Significance between control mice in different conditions (P < 0.05).