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. 2014 Nov 20;4:7139. doi: 10.1038/srep07139

Figure 6. SP2043 inhibits tumor-conditioned media induced lymphangiogenesis and angiogenesis within pre-metastatic organs.

Figure 6

(a) Activity of SP2043 in LEC tube formation induced by TCM at 18 h. SFM was used as a negative control. Scale bars represent 200 μm. (b) From the metastasis models in Fig. 5, we selected SFM-, TCM-, and SP2043-treated LN and lungs without metastases. These selected organs were stained with anti-mouse LYVE-1 and anti-mouse lectin. TCM treated LN showed enhanced lymphangiogenesis and angiogenesis, but SP2043 treatment inhibited them (upper). SP2043 inhibited the increased lymphangiogenesis seen in the lungs of animals treated with TCM. Angiogenesis, however, was not significantly influenced by either TCM or SP2043 (lower). Scale bars represent 1,000 μm. (c) Quantification of (b) upper panels (*P < 0.05). (d) Quantification of (b) lower panels (*P < 0.05). Data (c,d) are reported as mean ± s.e.m.