Table 3.
Comparison of synthetic methodologies for TPP
Lindsey synthesis | Mechanochemical condensation step | Two-step Mechanochemical | |
---|---|---|---|
E factor | 2784 | 1682 | 19.7 |
EcoScalea | −46 | −33.5 | 6.64 |
Tables showing the penalty points for each category of the EcoScale calculation can be found in Electronic Supplementary Information.