Table 2.
PAD and Post-PAD Mortality by Treatment Group
Chlorthalidone | Amlodipine | Lisinopril | Amlodipine vs. chlorthalidone | Lisinopril vs. chlorthalidone | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Number of events | 6-Year rate per 100 persons (SE) | Number of events | 6-Year rate per 100 persons (SE) | Number of events | 6-Year rate per 100 persons (SE) | HR (95 % CI) | P | HR (95 % CI) | P | |
PAD | 402 | 3.2 (0.2) | 198 | 2.7 (0.2) | 230 | 3.4 (0.3) | Univariate: | |||
0.82 (0.70–0.98) | 0.027 | 0.96 (0.82–1.13) | 0.651 | |||||||
Multivariate*: | ||||||||||
0.86 (0.72–1.03) | 0.099 | 0.98 (0.83–1.17) | 0.847 | |||||||
10-Year rate per 100 persons (SE) | 10-Year rate per 100 persons (SE) | 10-Year rate per 100 persons (SE) | ||||||||
Post-PAD mortality | 258 | 74.2 (3.0) | 119 | 74.5 (5.8) | 143 | 73.2 (4.7) | Univariate: | |||
0.92 (0.74–1.15) | 0.454 | 0.95 (0.77–1.18) | 0.651 | |||||||
Multivariate*: | ||||||||||
0.96 (0.76–1.23) | 0.762 | 1.01 (0.80–1.27) | 0.918 |
*Adjusted for baseline variables of age, race, ethnicity, gender, heart rate, pulse pressure, aspirin use, history of atherosclerotic cardiovascular disease, history of coronary heart disease, history of diabetes, current smoking, ever smoking, BMI, and estimated glomerular filtration rate