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Pathological examination of pancreatic islets in db/db mice. (a) Pancreatic islet from a normal mouse. (b) Pancreatic islet from db/db mouse with no treatment shows severe degranulation of most β-cells in this islet. (c) Pancreatic islet from db/db mouse treated with metformin. (d), (e), and (f) Pancreatic islet from db/db mouse treated with TNTL at the dose of 3.6 g, 1.8 and 0.9 g/kg b.w., respectively.
