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Pathological examination of renal tubule in db/db mice. (a) Renal tubule from a normal mouse. (b) Edema and degeneration of renal tubular epithelial cell from db/db mouse with no treatment. (c) Edema and degeneration of renal tubular epithelial cell from metformin-treated db/db mouse. (d), (e), and (f) Alleviation of degeneration of renal tubular epithelial cell from TNTL-treated db/db mouse at the dose of 3.6 g, 1.8 and 0.9 g/kg b.w., respectively.
