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. 2014 Dec;20(12):1878–1889. doi: 10.1261/rna.045633.114

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© 2014 Zhang et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 4. — TATA-box motif-specific miRNAs enhance the promoter activity of many important cellular genes. (A) Predicted interactions between the core promoter of four human genes and four human miRNAs. TATA-box motifs were highlighted. (B) The promoter activities of indicated genes were measured with dual-luciferase assay upon the overexpression of their corresponding miRNAs. The promoter-driven luciferase reporters were transfected into HEK293T cells with synthesized miRNA mimics or miRNA precursors containing construct. P-values were calculated using the two-tailed unpaired Student's t-test with equal variances, n = 3 biological replicates. (*) P < 0.05.