Figure 2.

γδTc may promote the tumor growth by different mechanisms. (A) According to Peng and colleagues, Vδ1Tc are attracted by IP-10 and migrate into the breast-tumor microenvironment. There they induce the senescence of αβTc and dendritic cells (DC), thereby suppressing an immune response. The induction of senescence can be abrogated in a TLR8 dependent manner. (B) Vδ2Tc, activated by IL-12 secreting DC, suppress αβ T cells and thereby potentially hamper an anti-tumor response of αβTc. (C) γδ17 T cells may support tumor progression by the promotion of angiogenesis and the induction of myeloid-derived suppressor cells (MDSC), which in turn suppress an αβTc immune response. The γδTc are depicted in red, αβTc in green and senescent cells in gray.