FIGURE 1.

Schematic showing the experimental design and timeline. IFN-γ knockout (KO) and wild-type (WT) littermate mice (n = 46 per genotype) were randomly assigned to a 6-week chronic stressor condition or a non-stress control group (n = 23; A). Mice of each condition were further divided into behavioral testing (n = 10; B) and behaviorally naïve cohorts (n = 13; C), the latter of which were used for end-of-study brain regional monoamine (n = 10) or hippocampal BDNF analyses (n = 3).