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Details of Protocol Therapy
| Drug and Dosage | Day |
|---|---|
| EZN-3042 (dose assigned at study entry) | −5, −2, 8, 15, 22, 29 |
| Vincristine 1.5 mg/m2 IV | 1, 8, 15, 22 |
| Prednisone 40 mg/m2/day PO | 1–29 |
| Pegaspargase 2500 IU/m2 IV | 2, 9, 16, 23 |
| Doxorubicin 60 mg/m2 IV | 1 |
| Intrathecal cytarabine | 0 |
| Intrathecal methotrexate | 15 and 36 (CNS negative) |
| Triple intrathecal chemotherapy | 8, 15, 22, 29 (CNS positive) |
