Table 1.
Demographic and polysomnographic data of 33 IPD patients and 37 age-matched controls
Mean ± SD or No. (%) | |||
---|---|---|---|
Variable | IPD patients | Controls | P |
Demographic data | |||
Age, y | 65.5 ± 11.6 | 66.7 ± 9.0 | 0.66a |
Sex: Men/women | 12/21 | 21/16 | 0.09 |
Educational level, y | 12.2 ± 3.7 | 12.6 ± 3.5 | 0.77b |
MMSE score | 28.82 ± 1.7 | 28.78 ± 3.0 | 0.95b |
BMI, kg/m2 | 25.3 ± 3.9 | 27.0 ± 4.0 | 0.08b |
Hoehn-Yahr stage | 2.0 ± 0.5 | – | – |
PD duration, y | 1.9 ± 1.3 | – | – |
Levodopa dosage, mg | 238.3 ± 331.5 | – | – |
Dopamine agonists, mgc | 1.0 ± 2.0 | 0.06 ± 0.3 | <0.01 |
Antidepressants | 8 (24) | 6 (16) | 0.40 |
Sedatives | 4 (12) | 5 (13) | 0.86 |
Total sleep time, min | 308.8 ± 58.0 | 325.8 ± 63.5 | 0.24b |
Polysomnographic data | |||
Total sleep time, min | 308.8 ± 58.0 | 325.8 ± 63.5 | 0.24b |
Sleep latency, min | 36.7 ± 27.3 | 36.3 ± 26.5 | 0.95a |
Sleep efficiency, % | 72.1 ± 15.2 | 74.4 ± 12.9 | 0.49a |
NREM sleep stage 2, min | 175.2 ± 47.0 | 176.4 ± 51.8 | 0.98d |
NREM sleep stage 2, % | 43.4 ± 11.4 | 44.5 ± 13.3 | 0.61b |
NREM sleep stage 3, min | 51.2 ± 45.7 | 61.9 ± 47.14 | 0.34a |
NREM sleep stage 3, % | 13.6 ± 12.0 | 14.6 ± 9.2 | 0.69a |
REM sleep stage, min | 43.0 ± 29.6 | 53.7 ± 25.9 | 0.09d |
REM sleep stage, % | 11.1 ± 7.1 | 13.6 ± 7.1 | 0.15a |
Index of apnea/hypopnea/h | 2.5 ± 4.9 | 2.1 ± 3.3 | 0.71a |
Index of periodic leg movements/h | 4.7 ± 14.9 | 5.8 ± 13.2 | 0.75a |
REM sleep muscle atonia, % | 79.9 ± 30.9 | 92.7 ± 22.4 | 0.0497a |
Awakenings/h | 6.0 ± 4.0 | 4.5 ± 3.2 | 0.10a |
Arousals/h | 7.8 ± 4.8 | 7.9 ± 6.7 | 0.94a |
Welch analysis of variance.
Mann-Whitney test.
Expressed in pergolide equivalents, with 1 mg of pergolide = 10 mg bromocriptine = 3 mg of ropinirole = 1 mg of pramipexole.
Analysis of variance (log values).
SD, standard deviation; IPD, idiopathic Parkinson’s disease; MMSE, Mini-Mental State Examination; BMI, body mass index; PD, Parkinson’s disease; NREM, non-rapid eye movement; REM, rapid eye movement.