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In vivo cytotoxicity of Ag-specific CD8 T cells after vaccination. Specific elimination of peptide-pulsed targets was measured simultaneously for both Gag-AI9–specific and Pol-LI9–specific CD8 T cell populations in vivo at day 10 (A) and month 3 (B) after vaccination with the indicated doses of Ad5.Gag.Pol. Statistical analyses were performed using the Wilcoxon matched-pairs signed-rank test.
