Table 2.
Sensitivity of SWI/SNF deletion strains to chemotherapeutic agents doxorubicin and cisplatin
| Strain | Doxorubicin
|
Cisplatin
|
||
|---|---|---|---|---|
| Survival (% ± SEM) | Sensitivity (fold) | Survival (% ± SEM) | Sensitivity (fold) | |
| Wild type | 100 | 1 | 100 | 1 |
| snf2 | 10±1.4 | 10 | 17±1.5 | 5.8 |
| snf5 | 76±7.2 | 1.3 | 85±6.5 | 1.2 |
| snf6 | 16±1.5 | 6.3 | 54±3.6 | 1.85 |
| snf11 | 59±3.6 | 1.7 | 48±20 | 2.1 |
| swi3 | 21±1.5 | 4.7 | 46±3.3 | 2.2 |
| swp82 | 24±6.3 | 4.2 | 76±12.3 | 1.3 |
| rtt102 | 27±3.5 | 3.7 | 39±11.8 | 2.5 |
| taf14 | 4±1.2 | 25 | 17±10 | 5.8 |
| ssz1 | 7±88 | 14 | 11±3.5 | 9 |
| ydj1 | 3±1 | 33 | 8±3.4 | 12.5 |
Abbreviation: SEM, standard error of the mean.