TABLE III. Demographical and clinical data in hepatitis B virus (HBV)-positive and HBV-negative Mexican children with clinical hepatitis from 2005-2009.
| Subject data | HBV-positivea | HBV-negativeb | pc |
|---|---|---|---|
| n (%) | 24 (11.2) | 191 (88.8) | - |
| Age (year) [mean ± SD (range)] | 6.8 ± 4.1 (1-15) | 7.3 ± 3.7 (1-15) | 0.584 |
| Sex [female/male (n/%)] | 11/13 (46/54) | 95/96 (50/50) | 0.718 |
| Clinical features [n (%)] | |||
| Time of onset of clinical symptoms: six months | 17/6 (70/30) | 169/13 (93/7) | 0.0004d |
| Jaundice | 21 (95) | 174 (97) | 0.560 |
| Hepatomegaly | 20 (91) | 176 (98) | 0.130 |
| Vomiting | 17 (74) | 145 (81) | 0.558 |
| Nauseas | 17 (77) | 144 (80) | 0.884 |
| Fever | 16 (73) | 129 (72) | 0.917 |
| Abdominal pain | 15 (68) | 127 (71) | 0.818 |
| Choluria | 13 (60) | 110 (61) | 0.855 |
| Acholia | 6 (27) | 53 (29) | 0.833 |
| Acute liver failure | 1 (4) | 5 (3) | 0.664 |
| ALT (UI/L) [mean ± SD (range)] (median) | 1,881 ± 5,290 (76-25,823) [629] | 1,272 ± 2,426 (40-25,894) [782] | 0.375 |
| AST (UI/L) [mean ± SD (range)] (median) | 670 ± 740 (64-2,650) [461] | 835 ± 955 (42-5,011) [415] | 0.453 |
| Direct bilirubin (mg/dL) [mean ± SD (range)] (median) | 3.5 ± 3.2 (0.31-12.3) [3.2] | 3.8 ± 4.3 (0.31-39) [3.2] | 0.626 |
| Albumin (mg/dL) [mean ± SD (range)] (median) | 4.1 ± 1.2 (1.5-6.1) [4.4] | 4.5 ± 1.1 (1.8-7.6) [4.6] | 0.222 |
| Anti-HAV IgM positive [n (%)] | 13/24 (54) | 92/113 (81) | 0.630 |
| Anti-HCV positive [n (%)] | 0 (0) | 2 (1) | 0.605 |
a: positive for HBV DNA in at least two different regions within the HBV genome; b: negative for HBV DNA; c: by t test, chi-square test or Fisher’s exact test; d: p < 0.05; ALT: alanine aminotransferase; AST: aspartate aminotransferase; SD: standard deviation.