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Model of regulation of the cytohesin-2/ARF6 pathway by PKC. (A) In resting platelets, cytohesin-2 (CYH2) is associated with ARF6 and maintains it in an active GTP-bound state, which constitutively suppresses dense granule secretion. (B) Upon platelet stimulation PKC is activated and phosphorylates cytohesin-2. This results in the dissociation of cytohesin-2 from ARF6, which therefore becomes inactive and GDP bound, allowing dense granule secretion to occur.
