Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Diagram demonstrating how TSC2 and mTORC1 are regulated in thrombin-activated human platelets. Early (1 min) TSC2 phosphorylation is regulated by PKC, whereas late (15 min) is regulated downstream of P2Y12 by PI3 kinase and PKC. mTORC1 activation requires concomitant PAR and P2Y12 signaling and either PKC or Src activation.
