. 2013 Aug 5;34(1):136–146. doi: 10.1111/liv.12264

Table 3.

Multivariate analysis of factors associated with survival and recurrence in cohort 2

Variable	TFS			OS
	Univariate P	Multivariate		Univariate P	Multivariate
	Univariate P	HR (95% CI)	P- value	Univariate P	HR (95% CI)	P- value
Age	0.965			0.488
Gender (male vs. female)	0.420			0.960
Child-Pugh (class A vs. class B)	0.346			0.965
AFP (≤400 ng/ml vs. >400 ng/ml)	0.454			0.638
Tumour diameter (<3.8 cm vs. ≥3.8 cm)	0.000^*	2.605 (1.313 to 3.247)	0.002^*	0.000^*	2.228 (1.429 to 3.625)	0.001^*
Number of nodules (single vs. multinodular)	0.035^*	1.149 (0.709 to 1.860)	0.573	0.054	1.313 (0.811 to 2.127)	0.269
BCLC Stage (stage A vs. stage B)	0.012^*	1.565 (0.958 to 2.559)	0.074	0.005^*	1.622 (1.027 to 2.562)	0.038^*
Tumour differentiation (well/mediately vs. poorly)	0.000^*	0.314 (0.130 to 0.756)	0.010^*	0.000^*	0.416 (0.277 to 0.627)	0.021^*
Site 7 methylation (<0.53 vs. ≥0.53)	0.001^*	0.435 (0.239 to 0.789)	0.038^*	0.002^*	0.672 (0.416 to 1.085)	0.025^*
Site 18 methylation (<0.52 vs. ≥0.52)	0.000^*	0.461 (0.256 to 0.832)	0.010^*	0.001^*	0.550 (0.330 to 0.916)	0.022^*

Univariate analysis, Cox proportional hazards regression model.

OS, overall survival; TFS, Tumour-free survival.

P < 0.05.