Table 2.
Metabolite concentrations and differences between groups
| Metabolites | Mean (SD) mmol/la | ||
|---|---|---|---|
| Controls | RRMS | PPMS | |
| tNAA | 10.658 (1.186) | 10.286 (0.746) | 10.105 (0.919) |
| Cho | 1.793 (0.199) | 1.938 (0.136)b | 1.762 (0.313) |
| Cr | 6.080 (0.387) | 6.294 (0.626) | 6.054 (1.076) |
| Ins | 5.864 (0.809) | 8.142 (5.734)c | 5.711 (0.896) |
tNAA, N‐acetylaspartate and N‐acetlylaspartylglutamate; Cho, choline‐containing compounds; Cr, creatine and phosphocreatine; Ins, myo‐inositol.
This table shows the mean value (and SD) of each metabolite concentration for each group of subjects. Each subject contributed to mean of the appropriate group with one number, representing the mean value of each metabolite concentration within each subject, regardless of voxel position along the CST; note that these values do not correspond to the tNAA mean values used in the statistical analysis, which were the individual values per subject per position.
Difference between RRMS and controls: P = 0.039.
Difference between RRMS and PPMS P = 0.037 (after adjusting for age, gender, and voxel tissue contents).