Table 1.

Summary of molecular interactions between oral streptococci and Candida albicans

Streptococcal molecules	Functional interaction with Candida	References
CshA	Binds to unidentified ligand(s) on C. albicans to promote coaggregation	Holmes et al., 1996; McNab et al., 1999
SspA/SspB	Bind to hyphae-specific ALS3 cell wall protein of C. albicans to promote coaggregation	Jenkinson & Demuth, 1997; Silverman et al., 2010
α-glucans	Synthesized by GtfB or GtfG to promote mixed biofilm accretion with C. albicans	Gregoire et al., 2011; Ricker et al., 2014
Autoinducer-2	Relieves farnesol repression of C. albicans hyphal growth	Bamford et al., 2009
Competence-stimulating peptide	Inhibits germ tube formation and stimulates hyphae-to-yeast transition	Jarosz et al., 2009
Streptococcus diffusible signal factors	Inhibit yeast-to-hyphae transition	Vilchez et al., 2010
Lactic acid	Decreases pH potentially affects pH- response gene expression	Calderone, 2002; Vylkova et al., 2011
H2O2	Oxidative and genotoxic stress, promotes filamentous growth	Barnard & Stinson, 1996; Nasution et al., 2008